Klinična študija zdravljenja osteoartritisa kolenskega sklepa z matičnimi celicami
Ljubljana, avgust 2017
Terapije z uporabo mezenhimskih matičnih celic sprožajo precej zanimanja v veterinarski medicini. V študiji, ki smo jo izvedli na Veterinarski fakulteti Univerze v Ljubljani smo ocenjevali uspešnost zdravljenja.
Mesenchymal stem cell therapies attract a lot of attention and also controversy in veterinary medicine. In the present study, mesenchymal stem cell therapy, using autologous cells from adipose tissue was evaluated for the treatment of osteoarthritis in the knee. Ten dogs with bilateral osteoarthritis in the knees were included in the study. After collection of adipose tissue and expansion of cells, 2 to 3 millions of mesenchymal stem cells were injected into one knee while sterile phosphate buffer (same as used for resuspension of cells) was injected into the other knee as a placebo.
Mechanisms involved in the therapeutic properties of mesenchymal stem cells
Elsevier, oktober 2019
Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the only characteristic that makes these cells attractive for therapeutic purposes. The secretion of a broad range of bioactive molecules by MSCs, such as growth factors, cytokines and chemokines, constitutes their most biologically significant role under injury conditions. Understanding this intricate secretory activity as well as the properties of MSCs in vivo is central to harnessing their clinical potential. Herein, we identify some of the molecules involved in the paracrine effects of MSCs with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and discuss how this knowledge could be advantageously used in clinical applications. More …